WebThe drug equivalent dose conversion ratio of mouse versus human is 9.1, and was adopted in this study. The clinical dose of Zuotai is 0.667 mg·kg −1; therefore, the equivalent dose in a mouse is 6.06972 mg·kg −1.The experiments were conducted with 1, 10, and 100 times the clinical equivalent doses of Zuotai in mice to explore the dose–effect relationship. Web8 Apr 2024 · For instance, the flavonoid isolated from milk thistle, silibinin, exerted antidepressant- and anti-anxiety-like effects in elevated plus maze test, tail suspension and forced swimming tests in MPTP treated mice and this was related to its ability to ameliorate damage to hippocampal 5-HT neurons (Liu et al., 2024).
Tail Suspension Test - an overview ScienceDirect Topics
Web31 Jan 2005 · To evaluate depression-related behavior, the forced-swim test and tail-suspension test were performed. No differences were detected between aged WT and KO mice in the forced-swim test at 12 or 20 months of age (Fig. 2D). In the tail-suspension test, aged KO mice spent more time immobile only during the third minute of the test. Web28 Jan 2012 · The tail-suspension test is a mouse behavioral test useful in the screening of potential antidepressant drugs, and assessing of other manipulations that are expected … cmiyc ミュージカル
The Tail Suspension Test Protocol - JoVE
WebTail suspension test (TST) 50 The total duration of immobility induced by tail suspension was measured according to the method described by Steru et al. (1985). 0 Mice both acoustically and visually isolated were suspended 50 cm above the floor by adhesive tape placed approximately 1 cm from B 0.5 1 2 4 6 8 12 the tip of the tail. WebTail suspension test was used to measure the depressive state of the mice. One-third of the mouse's tail was fixed to a rod, which was hung over the center of the box turning the mice... Web2 Jun 2024 · The tail suspension test is a method in which a mouse or rat is hung by attaching its tail to a box or rod using adhesive tape or similar material 6. The behaviour … c-mix シーミックス