WebSep 14, 2024 · [0126] Without being bound by theory, Applicants postulate that glycopeptides comprising sialic acid structures are similar to structures on the surface of tumor cells (e.g., melanoma tumor cells, CRC) and therefore activate the anti-cancer activity of immune cells (e.g., T cells) via binding to lectins on the immune cell surface (i.e., … Lectin-based techniques, including lectin microarray, lectin-affinity enrichment, and enzyme-linked lectin assay (ELLA), are extensively used for studying specific glycan structures in vitro.7 However, due to the transient and weak nature of glycan-mediated interactions, glycans need to be in their native … See more The fraction of the putative glycoprotein targets that were oxidatively labeled yields the sensitivity of the lectins. When all lectins were used, the total number of … See more
結合化學與酵素方法合成雙爪與三爪N-Glycans及其模仿化合物__國 …
WebMar 21, 2024 · Specifically, sialic acid–binding lectin purified from bullfrog ( Rana catesbeiana) eggs (cSBL) has potential as a cancer treatment due to its antitumor activity … WebMar 29, 2024 · Data suggest that sialic acid-binding Ig-like lectin-9 (Siglec-9)may serve as a potential diagnostic and therapeutic target for rheumatoid arthritis (RA). The mechanism … eastern states with elk hunting
Purexa™ SA -for purification via affinity to sialic acid — Purilogics
WebPreferred lectins applied in the context of the present invention are described herein. Also included by the term "lectin" are Siglecs (sialic acid-binding immunoglobulin-like lectins). Notably, the term "lectin" when used herein also refers to glycan-binding antibodies. WebWe found that a sialic acid-binding lectin (SABL) from bullfrog egg bears a remarkable degree of similarity with human angiogenin and the pancreatic ribonucleases (EC 3.1.27.5). Based on (1) the conservation of several disulfide bond-forming cysteines, (2) a cluster of nonpolar residues, and (3) a number of active-site residues of bovine ribonuclease, we … WebJan 17, 2024 · Sialic acid–binding immunoglobulin-like lectins (Siglecs) play important roles in recognizing sialylated glycans and in regulating immune homeostasis. 17 Siglec-15, a … culbertson surname