WebApr 10, 2024 · Obesity is a common complex trait that elevates the risk for various diseases, including type 2 diabetes and cardiovascular disease. A combination of environmental and genetic factors influences the pathogenesis of obesity. Advances in genomic technologies have driven the identification of multiple genetic loci associated with this disease, ranging … WebMar 2, 2024 · Monogenic traits are traits like face freckles or a cleft chin, which result from the product of a single gene. Polygenic traits are traits such as height or eye color that …
Dyslipidemia, inflammation, calcification, and adiposity in aortic ...
WebNov 15, 2024 · Polygenic hypercholesterolemia (PH) is a genetic condition that causes high cholesterol. It is characterized by increased levels of low density lipoprotein (LDL) … WebJun 27, 2024 · Polygenic hypercholesterolemia is a familial condition where there is an elevation in serum cholesterol levels due to mutation in several small LDL raising alleles. The mutation is detected using 12 single … how do you benchmark salaries
Genetics and epigenetics in the obesity phenotyping scenario
WebThe genetic predisposition to obesity must thus be polygenic; a number of such variants should be found in most obese subjects; however, these variants predisposing to obesity are also found in normal weight and even lean individuals. Therefore, a polygene can only be identified and validated by statistical analyses: the appropriate gene ... WebJul 24, 2024 · Difference between multiple alleles and polygenic traits definition. Multiple alleles: Multiple alleles refer to a series of three or more alternative forms of a gene. Polygenic traits: The polygenic trait is a trait that is controlled by a group of non-allelic genes. Presence in an individual Web10 hours ago · Using single-cell RNA sequencing, researchers identified 12 atherosclerosis-associated cell states and found that Vcam1+ smooth muscle cell state contributed the most to the genetic heritability of coronary artery disease. A hybrid polygenic risk score (PRS) that considers cell-type-specific regulatory elements demonstrated improved … how do you bend aluminum tubing