WebAug 13, 2024 · Results: The combination of fosfomycin and cryptotanshinone had a synergistic effect on most (71.43%) of the FRSA and had a partial (28.57%) synergistic effect on a small part. In addition, time sterilization curve verified synergistic activity between cryptanshinone and fosfomycin against FSSA and FRSA, especially when fosfomycin was … WebAug 23, 2024 · Cryptotanshinone (Cry) has multiple potential functions in treating different diseases. Most studies on Cry focus on its pharmacological effects and mechanisms, but toxicological reports on Cry are rare. Zebrafish is used as a model organism in drug development as it saves costs and time. This work aimed to investigate the toxicity of Cry …
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WebMar 2, 2024 · Cryptotanshinone (CPT), as a major component of Salvia miltiorrhiza Bunge (Danshen), displays many pharmacological activities including anti-inflammatory effects. However, the exact cellular and molecular mechanisms of the anti-inflammatory activities of CPT remain to be elucidated. The present study was aimed to clarify its mechanisms on … WebCryptotanshinone 是一种STAT3抑制剂,无细胞试验中IC50为4.6 μM,强烈抑制STAT3 Tyr705磷酸化,对STAT3 Ser727作用效果弱,对STAT1和STAT5没有作用效果 … circle back around
Comparative Proteomics Analysis Reveals the Reversal Effect of ...
WebCryptotanshinone is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Recently it was discovered that the compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3 ... WebIn this review, we intend to summarize the anti-cancer properties of Cryptotanshinone (CPT), an extract of Danshen (the root of Salvia miltiorrhiza Bunge), on different types of cancer. Cancer is among the most life-threatening diseases worldwide. Along with conventional therapies like chemotherapy, surgery, and radiotherapy, alternative ... Web2.4 Antitumor. Tanshinone IIA, cryptotanshinone and tanshinone I are the main antitumor ingredients of Salvia miltiorrhiza. The antitumor mechanisms of tanshinone IIA are as follows: (1) inhibiting the growth and proliferation of cancer cells, (2) inducing apoptosis, (3) inducing cell cycle arrest, and (4) inhibiting the invasion, migration and ... diamana whiteboard 83x